Theses - Science ITS
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A study of the practicality of cell-free protein synthesis for the commercial manufacture of monoclonal antibodies /
(ATU Sligo, 2022)Background: Monoclonal antibodies are tetrameric proteins with a complex folded structure, bound together by numerous disulfide bonds, and decorated with a functionally important oligosaccharide. Current production methods ... -
Theoretical investigation of optical fibre surface plasmon resonance palladium-based hydrogen sensors /
(Institute of Technology, Sligo, 2019 (grad)This thesis is an investigation into the operation and optimization of a series of optical fibre surface plasmon resonance (OFSPR) based hydrogen sensors. All devices we investigate are based on a multimode optical ... -
Ternary chalcogenides and their composites with titanium dioxide for photocatalytic applications /
(IT Sligo, 2021)This thesis addresses the preparation of semiconductor nanomaterials and their composites with ternary chalcogenides (TC) for photocatalytic applications. Rapid depletion and ever-increasing demand for fossil fuels ... -
The construction, survival, and use of signal defensible guard houses on the Irish coast /
(2021)In the first decade of the 19th century a new system of 81 military signal stations were constructed around the Irish coast. At 74 signal stations, purpose-built signal defensible guard houses were constructed, and some ... -
Development of fungal expression plasmids to facilitate promoter profiling and gene silencing studies in Coprinopsis cinerea /
(2020)The ink cap mushroom Coprinopsis cinerea (formally Coprinus cinereus) has long been regarded as one of the best model systems for the study of basidiomycete fungi. Most attention in C. cinerea has been focused on processes ... -
Challenges for the Regulatory Affairs Function in Demonstrating Compliance for Existing CE Marked Devices to the New EU Medical Devices Regulation 2017/745 /
(2019)The Medical Device industry in Europe, and specifically Ireland, is a critically important manufacturing sector underpinned with strong potential for further growth in the coming years. To place any Medical Device on the ... -
Application of geometric morphometrics to modern and zooarchaeological cattle bones /
(Institute of Technology, Sligo, 2019) -
The physiology and molecular biology of microalgae for the biorefinery of high-value metabolites /
(Institute of Technology, Sligo, 2019) -
Stone beads from Irish passage tombs: symbolism, social identity and the self /
(Institute of Technology, Sligo, 2019)In pre-industrial societies beads act as a medium of symbolic and social expression. Their role as a communication media means they affect all aspects of society from domestic and social life to ritual action. Determining ... -
Mirror therapy and treadmill training for patients with chronic stroke : a pilot randomised controlled trial /
(Institute of Technology, Sligo, 2019) -
Anatase to rutile transition in titanium dioxide photocatalytic nanomaterials /
(Institute of Technology, Sligo, 2019)Anatase and brookite are both considered metastable phases and transition irreversibly into the thermodynamically stable rutile phase at elevated temperatures (600-700°C in pure synthetic TiO2). Anatase TiO2 is widely ... -
Controlled release of the histone deacetylase inhibitor sodium butyrate for increasing recombinant protein production /
(Institute of Technology, Sligo, 2019)Improving the yields of biopharmaceutical products from mammalian cell culture is of paramount importance to manufacturing companies; increasing product yield includes enhancing recombinant gene expression in mammalian ... -
A real-time alert system for predicting and managing short-term pollution and bathing water quality at Enniscrone beach /
(Institute of Technology, Sligo, 2019)Under the Bathing Water Directive [2006/7/EC] there is a new highest microbiological quality classification of “Excellent” that is much more stringent than the highest standard of the old directive. This has serious ... -
A review of chromatography methods for the large scale downstream protein purification of monoclonal antibodies /
(Institute of Technology, Sligo, 2019)Researchers have continually proposed new non-chromatographic methods for manufacturing biopharmaceutical products. However, this report will show that chromatography remains the backbone of the downstream operation. ... -
An alternative to Triton X-100 for use in viral inactivation for recombinant factor VIII /
(Institute of Technology, Sligo, 2019)Solvent detergent combinations for viral inactivation have long been used in the manufacture of Biopharmaceutical products due their proven safety record for inactivating viruses. Triton X-100, a non-ionic detergent, has ... -
European Clinical Trial Medical Device Regulation and the Protection of Human Participants /
(Institute of Technology, Sligo, 2018)The focus of this research is in the area of European clinical trial regulation for medical devices to determine if the health and welfare of human participants is protected. There were four questions to be addressed: 1) ... -
Investigation of the mineral profile of Fucus serratus Linneaus aqueous extracts and examination of the routes of uptake of minerals both in vivo and in vitro /
(Institute of Technology, Sligo, 2018)Seaweed baths are used to promote health and well-being. Seaweed typically contains water, fibre, carbohydrate, protein, lipid, vitamins and minerals. Minerals can account for up to 40% of its composition. Iodine is vital ... -
Unilateral strength training and mirror therapy for enhancing upper limb motor function post stroke /
(Institute of Technology, Sligo, 2019)Cross-education of strength appears to be beneficial in the rehabilitation of injuries and illnesses causing bilateral asymmetry. Furthermore, evidence for the effectiveness of mirror therapy to enhance cross-education in ... -
Unilateral strength training and mirror therapy for enhancing lower limb motor function after stroke /
(Institute of Technology, Sligo, 2019)Stroke is the leading cause of adult disability. Hemiparesis and spasticity are common impairments, resulting in ankle dorsiflexion dysfunction and gait asymmetry. Often the most-affected side is too weak to engage in ... -
Multiregional Medical Device Registration /
(Institute of Technology, Sligo, 2017)The landscape of multiregional medical device registration is an area with highly variable regulations, varying regulator application and expectations, alongside swift changes in some regions. Accessing international ...
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