Theses - PRISM: Polymer, Recycling, Industrial, Sustainability and Manufacturing Institute
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The development of smart 4D materials utilising smart temperature responsive polymers
(Technological University of the Shannon: Midlands Midwest, 2023)This study involved the preparation and optimisation of novel temperature-sensitive hydrogel copolymer and terpolymer systems, and also the development and evaluation of smart hydrogels with the potential for 4D printing ... -
Deep Eutectic solvents and green reagent based process for polyethylene terephthalate depolymerisation
(Technological University of the Shannon: Midlands Midwest, 2023-09)Polyethylene terephthalate (PET) is a ubiquitous thermoplastic polymer which has numerous industrial applications including textile, construction, and packaging applications due to its versatile nature, transparency, ... -
A versatile monitoring technique for real-time protein activity tracking within cellular and biomimetic scaffold environments
(Technological University of the Shannon: Midlands Midwest, 2023-07-12)High biological noise is intrinsic within biological systems, and this poses critical challenges to the in-situ detection and measurement of biomolecular and protein activities important to advancing approaches to ... -
Integrating 3D printing and injection molding for mass customization: advancements in hybrid manufacturing
(Technological University of the Shannon: Midlands Midwest, 2023-08)Additive manufacturing (AM) is renowned for its ability to create complex geometries and customized products but is limited by low throughput. Conversely, injection molding (IM) excels in high-volume production but ... -
The optimisation of biomimetic scaffold fabrication for the controlled release of Osteogenic factors for bone tissue regeneration
(Technological University of the Shannon: Midlands Midwest, 2023-08)Bone tissue defect is a rising global concern and is one of the leading causes of morbidity and disability in patients. Bone regeneration treatments that demonstrate all key characteristics for successful bone healing: ... -
Novel technologies and optimised formulations for delivery of solid dispersion of BCS class II drugs
(Technological University of the Shannon: Midlands Midwest, 2023-06)The optimal design of amorphous solid dispersion (SD) formulations require the use of excipients to maintain supersaturation and improve physical stability in order to ensure shelf-life stability and better absorption ... -
Enhancing drug solubility through advanced polymer extruded shellac-based matrix drug delivery systems
(Technological University of the Shannon: Midlands Midwest, 2022-09)The main objective of this study is to enhance the solubility of the model drug fenofibrate, by forming amorphous solid dispersions using a hot melt extrusion process. Hot melt extrusion offers an efficient way of ... -
Development of drug eluting biodegradable nanocomposite for use in coronary stents
(Athlone Institute of Technology, 2021-07)Coronary stents are the scaffolds placed inside the blocked arteries, which aids the restoration of the passage of blood to the heart. Coronary stenting has become a standard medical procedure to treat coronary heart disease ... -
The development of advanced smart polymer formulations for potential biomedical applications.
(Athlone Institute of Technology, 2020-10)In the past twenty years, a theme in the pharmaceutical industry is to move towards more efficient use of active pharmaceutical ingredients and the need for improved delivery systems. Smart polymers throughout the literature ... -
A novel manufacturing technique for the production of tailored solid dosage forms
(Athlone Institute of Technology, 2020)The main objective of this study was to evaluate manufacturing processes for the fabrication of tailored solid dosage forms. Two hot-melt extrusion based manufacturing processes were investigated, a 3D printing process ... -
Synthesis and characterisation of novel n-vinyl pyrrolidinone/acrylic acid copolymers for use in biomedical applications.
(2006)The aim of this study was to develop a novel hydrophilic polymer for use in biomedical applications. The polymers synthesised in this work were based on the monomers N-vinyl pyrrolidinone (NVP) and acrylic acid (AA) and ... -
Development of novel monolithic matrices for drug delivery using conventional and non-conventional polymer processing technologies.
(2007)The aim of this study was to produce a range of polymer based monolithic matrices for controlled oral drug delivery using conventional polymer processing equipment. Poly (ethylene oxide) (PEO) was chosen as the primary ...
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