Development of Amoxicillin loaded microspheres for anti-Helicobacter pylori infection using Ionic Gelation method

Abstract

The aim of this project was to develop microspheres loaded with Amoxicillin for anti-Helicobacter pylori infection. Amoxicillin loaded microspheres were developed using blends of natural polymers such as Alginate and Chitosan using an Ionotropic gelation method. In this study, the physiochemical properties such as particle size, surface morphology, production yield, drug loading, entrapment efficiency, swelling index, and in vitro drug release mechanism were analysed. From this study, it was found out that AMX06 had the highest particle size (653μm) and drug loading (68%) while AMX01 had the highest production yield and entrapment efficiency (80%). All formulations demonstrated a burst drug release profile and AMX04 provided the best drug release profile (89%) after 6 hours. The FTIR analysis proved that a reaction had been established between the materials with the presence of a peak at 1772 cm-1 indicating the presence of a β-lactam ring of Amoxicillin and peak at 1580 cm-1 indicates the N-H bending of Chitosan amino group.