The development of novel bioresorbable medical devices for treating diseases of the anal canal

Abstract

Anal abscesses and fistulae in ano are the most prominent diseases of the anal canal Abscesses are pockets of pus caused by accumulating bactera whereas fistulae in ano are hollow tunnels that protrude from the wall of the anal canal to the buttocks These diseases pose a significant burden on the medical sector and a ffect a patient's quality of life through associated pain, embarrassing discharge and sexual impairment ( et al 2000 Introduction Aims and Objectives The transition from biologically stable materials to bio resorbable ones has become increasingly f avourable among clinicians due to the associated issues with current implant biocompatibility and the disadvantages of conducting revision surgeries (Nair Laurencin, 2007 Our focus is to modify the innate characteristics of polydioxanone ( a synthetic bioresorbable polymer, to support the regeneration of proximal tissue while locally delivering drugs.