An investigation into the effect of hyaluronic acid (HLA) polymer size on neuronal and glial cell viability and attachment

Abstract

HLA is a human endogenous biopolysaccharide discovered by Karl Meyer in 1938, in the vitreous humour of bovine eyes and is a key component of the extracellular matrix (ECM) found in every cell type in the body. It is naturally synthesized by a class of integral membrane proteins called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. .