Hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded delivery system
Date
2022Metadata
Show full item recordAbstract
Cardiovascular diseases (CVDs) are the number 1 cause of death
globally. Fenofibrate has been shown an excellent treating effect
on CVDs. However, Fenofibrate is a neutral, lipophilic compound
that is practically insoluble in water, making it challenging to
achieve therapeutic levels consistently. As a result, this project was
using shellac material as the polymeric matrix to enhance the
solubility of Fenofibrate by producing solid dispersion by hot melt extrusion
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