Functionality of gold-edge-coated triangular silver nanoparticles in monitoring extracellular matrix protein conformations in C2C12/MC3T3-E1 culture in the presence of biomimetic bone tissue regeneration scaffolds

Abstract

In the cellular environment high noise levels can both mediate and interfere with cellular functions.The extracellular matrix (ECM) regulates protein dynamics and trajectories, which underpin critical biological processes involved in the development of human disorders and healing processes, FRET and Raman Spectroscopy are conventional techniques for the study of proteins, however, they are elaborate, and their signals are hindered by the high noise levels of cellular environments.