Production and testing of the flat faced tablets via overprinting of injection moulded tablet bases

Abstract

Conventional drug production assures the merits of maintaining unit dosage form accuracy, stable dose and invariability among the batches. It also has a shortcoming that cannot make personalised medicine that could target different individuals. 3D printing manufacturing technique allows for tailored dosage forms for individual patients by providing precision medicine solutions; however, it’s hard to scale up efficiently. Injection moulding has been applied in the pharmaceutical area for a long time. It is available for the high production of tablets, but when it’s involved in personalised customisation, it’s neither cost-saving nor the simple making of designed moulding tooling. Overprinting is a proposed approach that combines the above two techniques to tailor the personalised solid dosage forms. It means to fabricate the injection moulded layer firstly then overprinting on the top of the tablet. All of the processes and testing results were implemented and presented.