Development of a new bone scaffold for the treatment of large bone defects

Abstract

Large bone defects remains a major problem in orthopaedic surgery despite these advances in medical techniques. To date, autogenous bone grafting is still commonly therapeutic standard. However, it presents some limitations associated with available bone volume, other complications and severe morbidity at the donor site. Bone tissue engineering has become one of promising methods to treat large bone defect due to its flexibility, biocompatible and osteoinductive. Composite scaffold with different formulations were prepared by the UV cross-link, and the properties of scaffolds were characterised by Fourier transform infrared (FTIR) spectroscopy and compression testing. The aim of this project is using biodegradable Composite scaffold to stimulate bone regeneration by controlling the releasing of active pharmaceutical ingredients