Browsing Department of Applied Science by Subject "Alzheimer's Disease"

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Polar lipids modify Alzheimer’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation

Hans, Sakshi; Stanton, Janelle E.; Sauer, Ann Katrin; Shiels, Katie; Saha, Sushanta Kumar; Lordan, Ronan; Tsoupras, Alexandros; Zabetakis, Ioannis; Grabrucker, Andreas M. (BioMed Central Ltd, 2024-04-20)

Background: Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (Aβ) peptides are a well-described pathology in Alzheimer’s disease (AD). Activated astrocytes surrounding Aβ plaques ...