Theses - Science ITS: Recent submissions
Now showing items 21-40 of 171
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An in vitro investigation into the anti-cancer potential of novel tetraoxane compounds for the treatment of chronic lymphocytic leukaemia /
(Institute of Technology, Sligo, 2018)This study aims to evaluate the therapeutic potential of five novel tetraoxane compounds and one novel tetraoxane-naphthalimide hybrid compound for chronic lymphocytic leukaemia. These novel compounds are predicted to ... -
An investigation into the compatibility and effectiveness of linking Brazilian carbon mitigation and trading strategies with the EU ETS (European Union Emissions Trading Scheme) /
(Institute of Technology, Sligo, 2018)International climate negotiations have recently underlined the relevance of international cooperation via carbon pricing, as well as the need for support from developed and developing countries to tackle climate change. ... -
Plethora of Potential Platforms: a review of current and future trends in expression system choice in the biopharmaceutical industry /
(Institute of Technology, Sligo, 2018)In the thirty years since the first biopharmaceuticals were approved for use in humans, the choice of expression system for new biopharmaceuticals has remained largely unchanged and is still mainly determined by the necessity ... -
A Review of recently Approved Orphan Designation Biological Drugs /
(Institute of Technology, Sligo, 2018)Orphan Drugs are a critical resource for those suffering from rare diseases and there is an urgent need for many new drugs to address the thousands of serious rare conditions which affect millions of people across the ... -
A Structured Analysis of the Novel Technologies used to alleviate bottlenecks in Biopharmaceutical Manufacturing /
(Institute of Technology, Sligo, 2018)Biopharmaceutical companies are under increasing pressure to meet the market demand from patients. Despite a high growth sector within the life sciences sector, the same types of manufacturing methods have been employed ... -
Microalgal phycoremediation of landfill leachate /
(Institute of Technology, Sligo, 2017)The aim of this project was to explore the use of microalgae in remediation of landfill leachate. The isolation of microalgae strains tolerant to a combination of high dissolved salts and ammonia concentrations (typical ... -
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An in vitro investigation of the antitumour efficacy of novel hybrids containing artemisinin, porphyrin, or naphthalimide derivatives /
(Institute of Technology, Sligo, 2017)Novel hybrid drugs have emerged as a promising new anticancer strategy. A hybrid drug is a compound in which two active ‘parent’ drugs are linked to create a single molecular entity with a multimodal action. The main ... -
Optimum global regulatory approaches for in-vitro diagnostic (IVD) instrumentation product development /
(Institute of Technology, Sligo, 2017) -
Investigation into the challenges encountered by regulatory affairs professionals working in the Medtech industry /
(Institute of Technology, Sligo, 2017)This research focused on the challenges experienced by Regulatory Affairs professionals working in the Medtech industry. Initial brainstorming with regulatory colleagues who have greater than ten years’ experience identified ... -
An analysis of medical device registration and market access in China /
(Institute of Technology, Sligo, 2017)The focus of this research is in the area of medical device registration and market access in China. Such a study is important as China is one of the largest markets for medical devices in the world making it an important ... -
Identification and quality assessment of high nature value (HNV) farmland in the North-West of Ireland.
(Institute of Technology, Sligo, 2015)High Nature Value (HNV) farmland is farmland that is managed at low intensity and which supports a high diversity of flora and fauna. HNV farmland has been acknowledged as being essential to the conservation of biodiversity ... -
An investigation of the trace organic contamination of Irish groundwater and a review of current analytical techniques
(Institute of Technology, Sligo, 1997)Groundwater is a major natural resource in Ireland. It has been estimated that 30% of the drinking water supply in Ireland is provided by this source. Most of the groundwater is of a potable quality but any contamination ... -
Establishment of a laboratory accredition system within the mining industry
(Institute of Technology, Sligo, 1995)Both metals and minerals are of pivotal importance to modem lifestyles and this situation will continue for the foreseeable future. Despite this obvious need for metals, people have a fear of the polluting emissions ... -
The role of statutory and non-statutory bodies charged with environmental responsibility in the Irish Republic
(Institute of Technology, Sligo, 1995)Primary responsibility for the protection of the environment in Ireland lies with the Department of the Environment, however many other government departments have both general and specific responsibilities in this ... -
Environmental education in primary schools
(Institute of Technology, Sligo, 2004)It is essential that people are educated in relation to the environment in order that sustainability is achieved. The younger that children are educated on these matters the greater the likelihood that it manifests itself ... -
Measurement of ambient concentrations of benzene, toluene and xylene in the vicinity of petrol service stations
(Institute of Technology, Sligo, 1999)Ambient air monitoring in the vicinity of three petrol service stations was undertaken to determine concentrations of three volatile organic compounds; benzene, toluene and xylene (BTX). Quantitative measurements were ... -
Rehabilitation of existing sewerage infrastructure
(Institute of Technology, Sligo., 2004)This dissertation has been produced for the research section of the Environmental Protection MSc, from Sligo Institute of Technology. The overall objective of the study was to highlight Infiltration and Exfiltration in ... -
Environmental management of the wastewater functions of a local authority
(Institute of Technology, Sligo, 2001)None -
A study into the implementation of S. I. no. 543 of 2002, "Emissions of volatile organic compounds from the organic solvents regulations, 2002" at local authority level
(Institute of Technology, Sligo., 2004)The vehicle coating and refinishing sector are facing increased regulatory and environmental pressures. This is a relatively novel experience for proprietors o f workshops, who because o f their subdued existence and ...
