Department of Pharmaceutical Sciences and Biotechnology: Recent submissions
Now showing items 21-40 of 71
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Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle
(Teagasc, 2010)Selection based on genetic polymorphisms requires accurate quantification of the effect or association of the polymorphisms with all traits of economic importance. The objective of this study was to estimate, using progeny ... -
Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples
(BMC, 2012-01-11)Background: The central role of the somatotrophic axis in animal post-natal growth, development and fertility is well established. Therefore, the identification of genetic variants affecting quantitative traits within ... -
Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF-1) gene are associated with performance in Holstein-Friesian dairy cattle.
(Frontiers, 2011-02-16)Insulin-like growth factor 1 (IGF-1) has been shown to be associated with fertility, growth, and development in cattle. The aim of this study was to (1) identify novel single nucleotide polymorphisms (SNPs) in the bovine ... -
A note on the use of FTA™ technology for storage of blood samples for DNA analysis and removal of PCR inhibitors
(Sciendo, 2009-01)FTA™ technology is widely used across many molecular disciplines for sample capture, storage and analysis. The use of this technology for the long-term storage of blood samples for DNA analysis was examined as well as ... -
The detection of endocrine disrupting chemicals leaching from reusable plastic water bottles.
(Athlone Institute of Technology, 2016)Endocrine disruption is a particular form of toxicity, where natural and/or endogenous compounds, known as “Endocrine Disrupting Chemicals”, cause adverse health effects by resulting in disruption to the endogenous hormone ... -
A population genomics analysis of the native Irish Galway sheep breed.
(Frontiers Media, 2019-10)The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as ‘at-risk’. In the present study, comparative population genomics analyses of Galway sheep ... -
Laboratory methods with graphic support as a UDL strategy for science students in laboratory sessions.
(AHEAD, 2019-03)The National Access Plan (2015-2019) provides a framework for broadening participation in higher education -
An investigation into the antibacterial and anti-inflammatory potential of an Irish Ivy Honey.
(Athlone Institute of Technology, 2018-02)A resurgence of interest into the medicinal uses of honey has occurred over recent years, with many investigations focusing on the healing properties of different monofloral honeys Amongst the most well known and well ... -
Examining adult learner and lecturer perspectives and experiences using audience response systems (clickers) in higher education.
(NPSE, 2019-03-21)This research investigated through action research the impact of clicker use on third level veterinary nursing students and their lecturer The study assessed how different methods of clicker use in class influenced ... -
A novel approach to analytical mineral analysis in the diagnosis of animal health.
(Athlone Institute of Technology, 2020-06)Minerals are nutrients that are essential for maintaining biological life. In animals they perform structural, physiological, catalytic and regulatory function. However when mineral deficiencies or toxicities occur ... -
Quantification of select minerals in animal serum and vitreous humour by inductively coupled plasma - optical emission spectrometry - ICP-OES
(Athlone Institute of Technology/Department of Agriculture, Food and the Marine, 2020-05)Mineral intake and balances are essential in maintaining good animal health and wellbeing. Mineral deficiencies and toxicities can have a detrimental impact on animal health. Important to diagnose these occurrences ... -
Investigation of the potential variation of toxins in bog-land water system.
(AIT, 2017)Irish bogs have suffered much damage from human activities such as peat extraction or agricultural works. Peat extraction is normally carried out with the use of drainage ditches to cause drying for ease of extraction. ... -
The investigation of land management practices on the soil ecosystem
(AIT, 2019)Ireland has a cool-temperate climate and frequent rainfall which provides a suitable environment for rich, arable soil. Agriculture has always been a crucial part of Irish society, sustaining the country’s food stocks and ... -
In vitro metabolism of the synthetic cannabinoid 3,5‐AB‐CHMFUPPYCA and its 5,3‐regioisomer and investigation of their thermal stability.
(Wiley, 2016-02)Recently, the pyrazole‐containing synthetic cannabinoid N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(cyclohexylmethyl)‐3‐(4‐fluorophenyl)‐1H‐pyrazole‐5‐carboxamide (3,5‐AB‐CHMFUPPYCA) has been identified as a ‘research chemical’ ... -
Untreated and enzyme-modified bovine whey products reduce association of Salmonella typhinurim, Escherichia coli O157:H7 and Cronobactermalonaticus (formerly Enterobacter sakazakii) to CaCo-2 cells.
(Wiley, 2010-02)Aims: Adhesion of a micro-organism to a cell surface is often considered to be the first step in pathogenesis. Inhibiting this process may have therapeutic effects in vivo. This study investigates the inhibitory effects ... -
Determination of the effect of dairy powders on adherence of Streptococcus sobrinus and Streptococcus salivarius to hydroxylapatite and growth of these bacteria
(Elsevier, 2011-06-12)Dental caries is a highly prevalent disease caused by colonisation of tooth surfaces by cariogenic bacteria, such as Streptococcus sobrinus and Streptococcus salivarius. Reducing initial adherence of such bacteria to teeth ... -
Influence of reconstitution temperature on survival of Cronobacter Sakazakii in powdered infant formula.
(Slovak University of Agriculture in Nitra. Faculty of Biotechnology and Food Sciences., 2016-04)Cronobacter spp. are emerging opportunistic pathogens commonly associated with the feeding of powdered infant formula (PIF). This study aimed to investigate the ability of C.sakazakii (ATCC 29544) to survive heat injury ... -
Comparative activity of silver based antimicrobial composites for urinary catheters.
(Elsevier, 2018-08-18)Biomedical polymers are an integral component in a wide range of medical devices because of their many desirable properties. However, extensive use of polymer materials in medical devices has been associated with an ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
(Elsevier, 2010-02-01)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.
(Elsevier, 2008-09-25)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...
