Bioscience Research Institute (Midlands): Recent submissions
Now showing items 41-60 of 103
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An investigation into the effect of hyaluronic acid (HLA) polymer size on neuronal and glial cell viability and attachment
(Athlone Institute of Technology, 2019-06)HLA is a human endogenous biopolysaccharide discovered by Karl Meyer in 1938, in the vitreous humour of bovine eyes and is a key component of the extracellular matrix (ECM) found in every cell type in the body. It is ... -
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
(Elsevier, 2022-02-25)Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ... -
Treatment for the amelioration of persistent factors in complex anal fistula
(Springer, 2021-11-19)Anal fistulae are abnormal hollow connections between the wall of the anal canal and the perianal skin around the anus that have remained a burden on the medical sector for centuries. The complexity of this disease is ... -
Application of biomaterials for complex anal fistulae
(Taylor & Francis, 2021-11-07)Complex anal fistulae remain a challenge for the medical sector as conventional treatments put patients at risk of incontinence. Clinicians and researchers have become interested in the application of bioresorbable ... -
In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications
(Nature Research, 2021-11)Natural mycelial biomass (MB) and exopolysaccharides (EPS) of Malaysian tiger milk mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. This study ... -
Microalgae as a natural ecological bioindicator for the simple real-time monitoring of aquaculture wastewater quality including provision for assessing impact of extremes in climate variance - a comparative case study from the Republic of Ireland
(Elsevier, 2021-08-17)Aquaculture is one of the fastest growing food producing industries globally, providing ~50% of fish for human consumption. However, the rapid growth of aquaculture presents a range of challenges including balancing ... -
In-vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian Tiger milk mushroom mycelius for potential future health applications
(Nature Research, 2021-08-12)Natural mycelial biomass (MB) and exopolysaccharide (EPS) produced from bioreactor-grown Malaysian Tiger Milk Mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in ... -
Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria
(Elsevier, 2021-08-10)Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study ... -
Genomes of Anguillid Herpesvirus 1 strains reveal evolutionary disparities and low genetic diversity in the Genus Cyprinivirus
(MDPI, 2021-05-05)Anguillid herpesvirus 1 (AngHV-1) is a pathogen of eels and a member of the genus Cyprinivirus in the family Alloherpesviridae. We have compared the biological and genomic fea tures of different AngHV-1 strains, focusing ... -
Integrative genomics of the mammalian alveolar macrophage response to intraceullular mycobacteria
(BMC, 2021)Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, ... -
Empower Eco multiactor HUB: A triple helix ‘academia-industry-authority’ approach to creating and sharing potentially disruptive tools for addressing novel and emerging new Green Deal opportunities under a United Nations Sustainable Development Goals framework
(Elsevier, 2021-06)There is a pressing drive to address climate change and environmental degradation that are global existential threats. Europe has strategically responded by unifying efforts to transform its connected communities into ... -
Disease-mitigating innovations for the pollination service industry: challenges and opportunities
(Elsevier, 2021-04)Commercially reared bumblebees are often deployed for fruit, vegetable, and seed crop pollination. Commercial bumblebee pollination contributes significantly to economic and nutritional security, thus maintaining healthy ... -
Bacterial inactivation, photoreactivation and dark repair post flow-through pulsed IV disinfection
(Elsevier, 2021-04-19)Pulsed UV (PUV) technology is accepted commercially for disinfection within the food packaging industry, but has yet to be deployed by the water/wastewater sector. This is partly due to a lack of robust, independently ... -
β-Glucan
(MDPI, 2021)β-glucans are a key active ingredient in mushrooms and are also found in oats, barley, yeast, bacteria and algae. In microbial sources, they are a structural component and in grain sources, they are found in the endospermic ... -
Investigations on the use of exopolysaccharide derived from mycelial extract of Ganoderma lucidum as functional feed ingredient for aquaculture-farmed red hybrid Tilapia ( Oreochromis sp.)
(Elsevier, 2021-02-03)There is growing interest in medicinal fungi for promoting immunomodulation benefits in humans and animals. In this study, exopolysaccharide (EPS) from Ganoderma lucidum was used in feed (EFF) on production of farmed-red ... -
Disposable face masks and reusable face coverings as non-pharmaceutical interventions (NPIs) to prevent transmission of SARS-CoV-2 variants that cause coronavirus disease (COVID-19): Role of new sustainable NPI design innovations and predictive mathematical modelling
(Elsevier, 2021-02-01)Best-published evidence supports the combined use of vaccines with non-pharmaceutical interventions (NPIs), to reduce the relative risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes ... -
Use of Zebrafish embryo assay to evaluate toxicity and safety of bioreactor-grown exopolysaccharides and endopolysaccharides from European Ganoderma applanatum mycelium for future aquaculture applications
(MDPI, 2021-02-07)Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applanatum mushrooms are of potential high commercial value for both food and adjacent ... -
β-glucan metabolic and immunomodulatory properties and potential for clinical application
(MDPI, 2020-12-10)β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ... -
A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix
(MDPI, 2020-12-06)This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating ...
