Abstract
According to the United Nations the global number of centenarians is set to continue to climb, expecting to reach more than 25 million people in 2100 [1]. As centenarians live at the furthest extremity of age, they have long been considered as representative of healthy aging [2][3]. The unprecedented growth of centenarian population cohorts and the heterogeneity in their phenotypes has led to the compromise that generally they can be considered as ambassadors for healthy aging [4][5][6]. The ideology of centenarians as a ‘model for positive aging’ is driven by the aforementioned need in modern society to distinguish the key factors contributing to advanced longevity.